Work

Do nonclassical, class Ib MHC molecules present bacterial antigens to T cells?

Year: 1993

Type: review

Abstract: Immune responses to bacterial antigens that appear unrestricted by the MHC may involve oligomorphic MHC class Ib molecules. One example is H-2M3, which binds N-formylated peptides and presents a Listeria peptide to cytotoxic T cells from infected mice. Lack of polymorphism makes these molecules a promising target for peptide vaccines.

Source: Trends in Microbiology

DOI: 10.1016/0966-842x(93)90023-k

Authors: Eric G. Pamer, Michael J. Bevan, Kirsten Fischer Lindahl

Institutions: Yale University, Howard Hughes Medical Institute, University of Washington, The University of Texas Southwestern Medical Center

Language: English

Topic: vaccines and immunoinformatics approaches

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030