Work

Developments in contraception: a comprehensive review of Desogen® (desogestrel and ethinyl estradiol)

Year: 1998

Type: review

Abstract: Table of ContentsPageHistorical Development of Oral Contraceptives1SPharmacology of Oral Contraceptives3SStructure-Function Relationships3SSelectivity for Progestogen and Androgen Receptors4SReceptor Binding Studies4SPharmacokinetics of Desogestrel5SAbsorption5SDistribution5SMetabolism and Excretion6SContraceptive Efficacy6SFormulations and Mechanisms of Action6SEffect on the Pituitary-Ovarian Axis6SEffect on Cervical Mucus7SContraceptive Reliability7SPatient Acceptance8SCycle Control8SDefinitions8SWithdrawal Bleeding8SAbsence of Withdrawal Bleeding9SDelay of Withdrawal Bleeding9SIrregular Bleeding (Intermenstrual Bleeding)9SEffect on Body Weight11SSubjective Adverse Effects11SNausea12SHeadache12SNervousness12SBreast Tenderness12SClinical Safety13SIntroduction13SEffects on Blood Pressure13SEffects on Lipid Metabolism14SEffects on Carbohydrate Metabolism16SEffects on Hemostasis16SEffects on Prostacyclin/Thromboxane Metabolism19SOral Contraceptives and Neoplasia19SNoncontraceptive Health Benefits of Oral Contraceptives20SOral Contraceptives and Neoplasia20SMenstrual and Other Gynecologic Disorders20SEffects on Hyperandrogenicity21SEffects on Sex Hormone Binding Globulin and Free Testosterone21SEffects on Acne and Hirsutism21SReferences22SSuggested Additional Readings26S

Source: Contraception

DOI: 10.1016/s0010-7824(98)00030-4

Authors: Paul Lammers, Paul D Blumenthal, George R Huggins

Institutions: Johns Hopkins University, Johns Hopkins Bayview Medical Center

Language: English

Topic: Reproductive Health and Contraception

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,500