Work

Potential Explanatory Factors for Higher Incident Hip Fracture Risk in Older Diabetic Adults

Year: 2011

Type: article

Abstract: Type 2 diabetes is associated with higher fracture risk. Diabetes-related conditions may account for this risk. Cardiovascular Health Study participants (N = 5641; 42.0% men; 15.5% black; 72.8±5.6 years) were followed 10.9 ± 4.6 years. Diabetes was defined as hypoglycemic medication use or fasting glucose (FG) ≥126 mg/dL. Peripheral artery disease (PAD) was defined as ankle-arm index <0.9. Incident hip fractures were from medical records. Crude hip fracture rates (/1000 person-years) were higher for diabetic vs. non-diabetic participants with BMI <25 (13.6, 95% CI: 8.9-20.2 versus 11.4, 95% CI: 10.1-12.9) and BMI ≥25 to <30 (8.3, 95% CI: 5.7-11.9 versus 6.6, 95% CI: 5.6-7.7), but similar for BMI ≥30. Adjusting for BMI, sex, race, and age, diabetes was related to fractures (HR = 1.34; 95% CI: 1.01-1.78). PAD (HR = 1.25 (95% CI: 0.92-1.57)) and longer walk time (HR = 1.07 (95% CI: 1.04-1.10)) modified the fracture risk in diabetes (HR = 1.17 (95% CI: 0.87-1.57)). Diabetes was associated with higher hip fracture risk after adjusting for BMI though this association was modified by diabetes-related conditions.

Source: Current Gerontology and Geriatrics Research

DOI: 10.1155/2011/979270

Authors: Elsa S. Strotmeyer, Aruna Kamineni, Jane A. Cauley, John A. Robbins, Linda F. Fried, David S. Siscovick, Tamara B. Harris, Anne B. Newman

Institutions: University of Pittsburgh, Kaiser Permanente Washington Health Research Institute, University of California, Davis, VA Pittsburgh Healthcare System, University of Washington, National Institutes of Health, National Institute on Aging

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $820

Funders: American Diabetes Association, Amgen, University of Pittsburgh, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke

Awards: G1002540797, G1177103769, G1220223050, G1224608327, G1345547317, G1401438683, G1412333385, CHS-ULTRASOUND READING, CORONARY HEART DISEASE AND STROKE, MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY, G1727292203, G1742450553, G1890355377, G1909643007, G2125948122, G2194386449, G236442059, G247538147, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), G274585943, G277826483, G2786044735, G2800149121, G2847759872, G2882309788, G3137375862, G3145043064, G3169706684, G328935669, G3370719899, G3507024915, G3560915123, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, Predictors of Alheimers Disease in Mild Cognitive Impairment, G4012114008, G4048755144, G423252844, G4365909528, G4405540675, G4660668308, G4987078009, G5167412771, G573134505, CHS Events Follow-up Study, G61834786, G6226795708, Predictors of Alzheimers Disease in Mild Cognitive Impairment, G640327682, CHS-Transition Phase, G6832344490, G687544517, G6923371013, G693548699, G7035200923, G7286144250, CHS RETINAL READING CENTER, G764651519, CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY, G766700449, G766843672, G777822606, CHS Events Follow-up Study, G7999488110, G806768229, G8593276544, G859984287, Pittsburgh Older Americans Independence Center, G905887895, G960597250

OpenAlex ID: W2032970094

FWCI: 1.222

Cites: 46

Cited by: 20

Related to: 10