Work

Preclinical models of antipsychotic drug action

Year: 2013

Type: article

Abstract: One of the main obstacles faced by translational neuroscience is the development of animal models of psychiatric disorders. Behavioural pharmacology studies indicate that psychedelic drugs, such as lysergic acid diethylamide (LSD) and dissociative drugs, such as phencyclidine (PCP), induce in healthy human volunteers psychotic and cognitive symptoms that resemble some of those observed in schizophrenia patients. Serotonin 5-HT2A and metabotropic glutamate 2 receptors have been involved in the mechanism of action of psychedelic and dissociative drugs. Here we review recent advances using LSD-like and PCP-like drugs in rodent models that implicate these receptors in the neurobiology of schizophrenia and its treatment.

Source: The International Journal of Neuropsychopharmacology

DOI: 10.1017/s1461145713000606

Authors: José L. Moreno, Javier González-Maeso

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Psychedelics and Drug Studies

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Alliance for Research on Schizophrenia and Depression, Dainippon Sumitomo Pharma, National Institutes of Health, National Institute of Mental Health