Work

Genes for endosomal NHE6 and NHE9 are misregulated in autism brains

Year: 2013

Type: article

Abstract: Autism is a highly heterogeneous neurodevelopmental disorder with impaired language, social communication, and restricted and repetitive interests and behavior. Monogenic developmental brain disorders with autism features such as Rett syndrome, Angelman syndrome, Fragile X syndrome, and others provide important tractable models of relevance to severe autism. In addition to observing autism symptoms in the monogenic condition, if the gene responsible is also significantly misregulated in the brains of people with idiopathic autism, then these data provide substantial independent support for the importance of the gene in autism pathophysiology.

Source: Molecular Psychiatry

DOI: 10.1038/mp.2013.28

Authors: M Schwede, K Garbett, K Mirnics, D H Geschwind, E M Morrow

Institutions: Brown University, Vanderbilt University, University of California, Los Angeles, Bradley Hospital

Language: English

Topic: Autism Spectrum Disorder Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,490