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Hepato‐biliary late effects in survivors of childhood and adolescent cancer: A report from the Children's Oncology Group

Year: 2009
Type: article
Abstract: Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.
DOI: 10.1002/pbc.22265
Authors: Sharon Castellino, Andrew Muir, Ami Shah, Sheila Shope, Kevin McMullen, Kathy Ruble, Ashley Barber, Andrew Davidoff, Melissa M. Hudson
Institutions: Wake Forest University Health Sciences, Wake Forest University, Duke University, Duke Medical Center, Children's Hospital of Los Angeles, St. Jude Children's Research Hospital, University of Tennessee Health Science Center, Johns Hopkins University, Johns Hopkins Hospital
Language: English
Field: Medicine
Open Access status: green
Awards: G1675133966, G2843309668, G301932103, G3647844574, Postdoctoral Training Program in Cancer Survivorship, G997771125
OpenAlex ID: W2033327655
FWCI: 1.327
Cites: 69
Cited by: 58
Related to: 10