Work

G Protein-coupled Receptors

Year: 1998

Type: review

Abstract: Nearly 2000 G protein-coupled receptors (GPCRs)1 have been reported since bovine opsin was cloned in 1983 (1) and the β-adrenergic receptor in 1986 (2). They are classified into over 100 subfamilies according to the sequence homology, ligand structure, and receptor function. A substantial degree of amino acid homology is found among members of a particular subfamily, but comparisons between subfamilies show significantly less or no similarity.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.273.28.17299

Authors: Tae H. Ji, Mathis Grossmann, Inhae Ji

Institutions: University of Wyoming, Walter and Eliza Hall Institute of Medical Research

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development