Work

Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.

Year: 1989

Type: article

Abstract: Antennapedia-class vertebrate homeobox genes have been classified with regard to their chromosomal locations and nucleotide sequence similarities within the 183-base-pair homeobox domain. The results of these comparisons support the view that in mammals and most likely the vertebrates, four clusters of homeobox genes exist that were created by duplications of an entire primordial gene cluster. We present evidence that this primordial cluster arose by local gene duplications of homeoboxes that were present before the divergence of arthropods and chordates. Sequence analyses indicate that the expansion of the primordial gene cluster complex was accompanied by diversification, whereas conservation predominated after the duplications of entire homeobox gene clusters.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.86.14.5459

Authors: C Kappen, K Schughart, F H Ruddle

Institution: Yale University

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Yale University, Deutsche Forschungsgemeinschaft, National Institutes of Health, National Institute of General Medical Sciences

Award: G38528603