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More than an accessory: implications of type III transforming growth factor‐β receptor loss in prostate cancer

Year: 2010

Type: article

Abstract: The type III transforming growth factor-beta receptor (TGFbetaR3, betaglycan), a tumour suppressor, is the most frequently lost TGFbeta pathway component. This event appears to be very important in the transition of the TGFbeta pathway from having tumour-suppressor activity in early prostate tumour development, to having tumour-promoting activity in metastatic disease. Moreover, loss of the TGFbetaR3 can also affect the cellular response towards testosterone, inhibin/activin, and dysregulate growth-factor pathways that mediate growth and angiogenesis. In this review we discuss how TGFbetaR3 normally functions as an accessory protein in the TGFbeta pathway, how its loss is related to tumour progression, and the treatment implications of TGFbetaR3 loss in individuals with prostate cancer.

Source: British Journal of Urology

DOI: 10.1111/j.1464-410x.2009.08999.x

Authors: Seun Ajiboye, Tristan M. Sissung, Nima Sharifi, William D. Figg

Institutions: National Cancer Institute, Center for Cancer Research, The University of Texas Southwestern Medical Center

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institutes of Health