Human T Cell Rapamycin Resistance And Th1/Tc1 Polarization Augment Xenogeneic Graft-Versus-Host Disease
Year: 2010
Type: article
Abstract: Adoptive transfer of co-stimulated T cells represents an immunotherapeutic method currently under clinical investigation. We hypothesized that the ex vivo acquisition of rapamycin resistance and type I cytokine polarization during co-stimulation would augment the in vivo effect of adoptively transferred human T cells. In the presence of rapamycin, T cell co-stimulation and polarization with IL-12 or IFN-γ permitted human CD4+ and CD8+T cell differentiation towards a Th1/Tc1 phenotype: by intracellular flow, median percentage expression of Foxp3, IFN-γ, and T-bet was 4%, 20%, and 72%, respectively.
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2033630653