Year: 1998
Type: review
Abstract: In the past two years we have entered the log phase for unraveling the molecular clockworks. Rapid progress in understanding the Neurospora clock has been complemented by a flood of information from diverse systems including cyanobacteria, insects and mice. There are broadly conserved features in transcription/translation based feedback loops. Conservation is also found at the sequence level, from fungi to mammals, in the PAS domains of the heterodimeric partners of the transcription factors that act as the positive components of the feedback cycle. Pivotal PAS proteins from Neurospora, the WCs, provide an evolutionary link connecting the clock in insects and mammals to the fungi and to light-harvesting proteins from bacteria.
Source: Current Opinion in Microbiology
Author: Jennifer J Loros
Institution: Dartmouth College
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,800
OpenAlex ID: W2033671191