Dopaminergic Challenge With Bromocriptine One Month After Mild Traumatic Brain Injury: Altered Working Memory and BOLD Response
Year: 2011
Type: article
Abstract: Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.
Source: Journal of Neuropsychiatry
Authors: T. W. McAllister, L. A. Flashman, B. C. McDonald, R. B. Ferrell, T. D. Tosteson, N. N. Yanofsky, M. R. Grove, A. J. Saykin
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Dartmouth College, National Institutes of Health, U.S. Public Health Service, National Institute on Disability and Rehabilitation Research, National Institute on Aging, National Cancer Institute, Fogarty International Center, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W2033811331