Medication Use in the Neonatal Intensive Care Unit
Year: 2013
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The aim of the article is to provide an update on medication use in infants admitted to the neonatal intensive care unit (NICU) in the United States and examine how use has changed over time. STUDY DESIGN: We performed a retrospective review (2005-2010) of a large prospectively collected administrative database. RESULT: Medications most commonly administered during the study period were ampicillin, gentamicin, caffeine citrate, vancomycin, beractant, furosemide, fentanyl, dopamine, midazolam, and calfactant (56-681 exposures per 1,000 infants). Those with the greatest relative increase in use included azithromycin, sildenafil, and milrinone. Medications with the greatest relative decrease in use included theophylline, metoclopramide, and doxapram. CONCLUSION: Medication use in the NICU has changed substantially over time, and only 35% of the most commonly prescribed medications are Food and Drug Administration -approved in infants.
Source: American Journal of Perinatology
Authors: Emily Hsieh, Christoph Hornik, Reese Clark, Matthew Laughon, Daniel Benjamin, P. Smith, on Behalf of the Best Pharmaceuticals for Children Act—Pediatric Trials Network
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Thrasher Research Fund, Children's Hospital of Philadelphia, University of Pennsylvania, George Washington University, Pennsylvania State University, Children's Mercy Hospital, National Institutes of Health, University of North Carolina at Chapel Hill, Penn State College of Medicine, National Heart, Lung, and Blood Institute, National Institute of Child Health and Human Development, Duke Clinical Research Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental Outcomes, G1955014951, PHARMACOKINETICS OF ANTIMICROBIAL AGENTS IN HIGH RISK INFANTS, G3008453, G3067593924, G3851912115, G4306857565, G5119124739, G5139652136, G55644326, G5584983125, Antimicrobial pharmacokinetics and outcomes in vulnerable infants, G6365708837, G6645485005, G7177219445, G7634447104, G7730008505, G7921418012, G8252581345, G8960167436, Mentorship of early-career pediatricians in quantitative methods and therapeutics
OpenAlex ID: W2033829367