Identification of Minimal Clinically Important Difference Scores of the PedsQL in Children, Adolescents, and Young Adults With Type 1 and Type 2 Diabetes
Year: 2013
Type: article
Abstract: OBJECTIVE: To establish minimal clinically important difference (MCID) scores representing the smallest detectable change in quality of life (QOL), using the Pediatric Quality of Life Inventory (PedsQL) Generic Core and Diabetes Module among youth with diabetes and their parents, and to identify demographic and clinical correlates of QOL change over 1 year. RESEARCH DESIGN AND METHODS: Participants in the SEARCH for Diabetes in Youth Study aged >5 years and parents of youth aged <18 years completed PedsQL surveys at their initial and 12-month study visits. MCIDs for each PedsQL module were calculated using one standard error of measurement. Demographic and clinical characteristics associated with QOL change were identified through multiple linear and logistic regression analyses. RESULTS: The sample comprised 5,004 youth (mean age, 12.5 ± 4.7 years; mean diabetes duration, 3.4 ± 3.7 years). Of 100 possible points, PedsQL total score MCIDs for youth with type 1 and type 2 diabetes, respectively, were Generic Core, 4.88, 6.27 (parent) and 4.72, 5.41 (youth); Diabetes Module, 4.54, 6.06 (parent) and 5.27, 5.96 (youth). Among 1,402 youth with a follow-up visit, lower baseline QOL, male sex, private insurance, having type 1 diabetes, longer diabetes duration, and better glycemic control predicted improvements in youth- and parent-reported PedsQL total scores over 1 year. Clinically meaningful (≥1 MCID) improvements in total score for at least one PedsQL module were predicted by private insurance, lower BMI, and lower A1C at baseline. CONCLUSIONS: These diabetes-specific reference points to interpret clinically meaningful change in PedsQL scores can be used in clinical care and research for youth with type 1 and type 2 diabetes.
Source: Diabetes Care
DOI: 10.2337/dc12-1708
Authors: Marisa E. Hilliard, Jean M. Lawrence, Avani C. Modi, Andrea Anderson, Tessa Crume, Lawrence M. Dolan, Anwar T. Merchant, Joyce P. Yi-Frazier, Korey K. Hood, for the SEARCH for Diabetes in Youth Study Group
Institutions: Johns Hopkins University, Johns Hopkins Medicine, Kaiser Permanente, Cincinnati Children's Hospital Medical Center, Wake Forest University Health Sciences, Wake Forest University, Colorado School of Public Health, University of Colorado Denver, University of South Carolina, University of Washington, University of California, San Francisco
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: U.S. Department of Veterans Affairs, Kaiser Permanente, Wake Forest University, University of Washington, National Institutes of Health, Centers for Disease Control and Prevention, U.S. Public Health Service, University of North Carolina at Chapel Hill, University of Colorado Denver, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Chronic Disease Prevention and Health Promotion
Awards: G1002765518, G1061576540, G1092462818, G1095442109, South Carolina Clinical & Translational Research Institute (SCTR), G142556933, G1517268644, G1615242365, G173331, G1841928114, UCHSC Diabetes and Endocrinology Research Center, G2027946723, G204141994, G206755211, G2091809135, G2249192922, G22646245, G2295491902, G2320993242, G244787544, Cincinnati Center for Clinical and Translational Sciences and Training, G248045910, G249568976, G2698360221, G2736310229, G278975345, G2962638713, G3013847213, G3146357332, G3227672145, G325765397, G327346145, G3437629819, G3539854705, G3753588054, G3783546076, G3798223455, G3861154396, G386564605, G3913620056, G4169180449, G4221519001, G4780661971, G492257343, G4976965329, G5105936691, G5166157367, G5263611099, G5424006154, G561931883, G5947551922, G5997117553, G600531474, G619635683, General Clinical Research Center, G6850813666, G6880221729, General Clinical Research Center, G6986679822, G7173154897, G7330461463, G7417637724, G7543494365, G7713430636, G7887614091, G7897290752, G8005556827, G8194560534, G821340895, G821379033, G822274331, G832786732, G847497056, G854732306, G874743574, G951231213, G993493546
OpenAlex ID: W2033855646