Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions
Year: 2010
Type: article
Study design: Observational Study
Abstract: We compared vaginal proinflammatory cytokine and secretory leukocyte protease inhibitor (SLPI) concentrations among pregnant and nonpregnant women according to bacterial vaginosis (BV) status. One-hundred and twenty-two women at 12-20 weeks' gestation and 133 nonpregnant controls had vaginal concentrations of interleukin (IL)-1β, IL-6, IL-8, and SLPI measured by enzyme immunoassay. Multivariable linear regression was used to evaluate factors independently associated with vaginal cytokine and SLPI response. Pregnancy and BV were both independently associated with increased vaginal concentrations of IL-1β and IL-8; pregnant women had increased concentrations of SLPI, while women with BV had decreased SLPI concentrations.
Source: Journal of Pregnancy
DOI: 10.1155/2010/385981
Institutions: University of Washington, Fred Hutch Cancer Center
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,000
Funders: Infectious Diseases Society for Obstetrics and Gynecology, National Institutes of Health, Centers for Disease Control and Prevention, Department of Mechanical Engineering, University of Texas at Austin, Agency for Toxic Substances and Disease Registry, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W2034062180