Brisket Disease. Iii. Spontaneous Remission of Pulmonary Hypertension and Recovery From Heart Failure*
Year: 1963
Type: article
Abstract: Previous reports from this laboratory have dealt with the ecologic, pathologic, clinical, and pathophysiologic features of brisket disease (1, 2).On the basis of these studies brisket disease may be defined as altitude-dependent, pulmonary, hy- pertensive heart disease in cattle of the species Bos taiurus.Briefly, the disease in Utah occurs primarily in young calves usually during their first exposure to conditions existing on summer ranges at elevations between 8,000 and 11,000 feet.Typical findings in animals suffering from brisket disease are outlined in Table 1.It was observed that a significant number of animals with acute brisket disease recovered when removed from the mountainous ranges and brought to Salt Lake City, Utah (elevation 4,500 feet).This observation prompted an investiga- tion of the nature, magnitude, and time course of changes in various physiologic parameters associated with clinical recovery.The demon- stration of dramatic remission from pulmonary hypertension and improvement in over-all cardio- vascular function provides the basis for this report.METHOD Over a period of 4 years, 43 venous and 21 left ventricular cardiac catheterization studies were carried out in 14 animals that recovered from brisket disease.These calves were among a group of 42 in which hemodynamic observa- tions were made during acute brisket disease.Five ani- mals were studied twice, six were studied three times, and four separate observations were made on the remaining three.The initial catheterization procedure in each ani-* This study was supported in part by grants from the Utah Heart Association, the U. S. Public Health Serv- ice (H-4299 and HTS-5150), and the American Heart Association.
DOI: 10.1172/jci104749
Institutions: University of Utah, Marquette University, University of London
Language: English
Topic: High Altitude and Hypoxia
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funder: American Heart Association
OpenAlex ID: W2034190924