Work

Vaccine Design Reaches the Atomic Level

Year: 2011

Type: article

Abstract: The genetic diversity of pathogens presents a challenge to the development of broadly effective vaccines. In this issue, Scarselli et al. combine atomic-level structural information with genomics and classical vaccinology to design a single immunogen that elicits protective immunity against more than 300 natural variants of the bacterial pathogen meningococcus B. This accomplishment provides a glimpse of the power of structure-based vaccine design to create immunogens capable of eliciting protective responses against genetically diverse pathogens.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.3002807

Authors: Peter D. Kwong, Lawrence Shapiro

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Vaccine Research Center, Columbia University

Language: English

Topic: Bacterial Infections and Vaccines

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases