Work

Isolation and Characterization of E–64, a New Thiol Protease Inhibitor

Year: 1978

Type: article

Abstract: A new thiol protease inhibitor, named E-64, was isolated from the extract of a solid culture of Aspergillus japonicus TPR-64 freshly isolated from soil.E-64 was obtained as white needles and the empirical formula was estimated to be C15N5-H27O5 (M.W. 357).This was almost neutral in its electrophoretic behavior and proved to be a specific and strong inhibitor toward thiol protease such as papain and cathepsin B. They combine equimolecularly and irreversibly.

Source: Agricultural and Biological Chemistry

DOI: 10.1080/00021369.1978.10863014

Authors: Kazunori Hanada, Masaharu Tamai, Michio Yamagishi, Sadafumi Ohmura, Jiro Sawada, Ichiro Tanaka

Institution: Taisho Pharmaceutical (Japan)

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2034296548

FWCI: 6.109

Cites: 5

Cited by: 369

Related to: 10