Work

Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands.

Year: 1978

Type: article

Abstract: A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity of the peptide is estimated to be 30% of the potency of ACTH. It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.75.9.4306

Authors: C H Li, D Chung, D Yamashiro, C Y Lee

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2034414253

FWCI: 1.629

Cites: 20

Cited by: 70

Related to: 10