Work

TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core

Year: 2012

Type: article

Abstract: TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to the HIV-1 core. Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 infection after nuclear import.

Source: Journal of Virology

DOI: 10.1128/jvi.00451-12

Authors: Jose Carlos Valle-Casuso, Francesca Di Nunzio, Yang Yang, Natalia Reszka, Maritza Lienlaf, Nathalie Arhel, Patricio Perez, Abraham L. Brass, Felipe Diaz-Griffero

Institutions: Albert Einstein College of Medicine, Institut Pasteur, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Massachusetts Institute of Technology

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institute of Mental Health, National Institute of Allergy and Infectious Diseases

Awards: Modulation of retroviral uncoating by cellular factors, Role of TNPO3 in HIV-1 Replication, Role of the B-box-v-1 Restriction by TRIM5alpha proteins, Harvard University Center for AIDS Research

OpenAlex ID: W2034500663

FWCI: 5.158

Cites: 22

Cited by: 90

Related to: 10