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Long and short isoforms of Neurospora clock protein FRQ support temperature‐compensated circadian rhythms

Year: 2007
Type: article
Abstract: The large (l) and small (s) isoforms of FREQUENCY (FRQ) are elements of interconnected feedback loops of the Neurospora circadian clock. The expression ratio of l-FRQ vs. s-FRQ is regulated by thermosensitive splicing of an intron containing the initiation codon for l-FRQ. We show that this splicing is dependent on light and temperature and displays a circadian rhythm. Strains expressing only l-FRQ or s-FRQ support short and long temperature-compensated circadian rhythms, respectively. The thermosensitive expression ratio of FRQ isoforms influences period length in wt. Our data indicate that differential expression of FRQ isoforms is not required for temperature compensation but rather provides a means to fine-tune period length in response to ambient temperature.
Source: FEBS Letters
DOI: 10.1016/j.febslet.2007.11.043
Authors: Axel Diernfellner, Hildur V. Colot, Orfeas Dintsis, Jennifer J. Loros, Jay C. Dunlap, Michael Brunner
Language: English
Open Access status: bronze
Awards: Functional Analysis and Systems Biology of Filamentous Fungi, G2393300283, Identification and Analysis of Circadian Clock-Controlled Genes, Genetic and Molecular Dissection of the Neurospora Clock, G4008756567, G7236649216, Genetic and Molecular Dissection of the Neurospora Clock
OpenAlex ID: W2034637152
FWCI: 2.724
Cites: 18
Cited by: 94
Related to: 10