Work

Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

Year: 2010

Type: article

Abstract: Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.

Source: European Psychiatry

DOI: 10.1016/j.eurpsy.2010.01.009

Authors: J.J. Mann, D.M. Currier

Institution: Columbia University

Language: English

Topic: Suicide and Self-Harm Studies

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Mental Health