Year: 2014
Type: review
Abstract: O-Linked -N-acetylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins.Analogous to phosphorylation, O-GlcNAcylation plays crucial regulatory roles in cellular signaling.Recent work indicates that increased O-GlcNAcylation is a general feature of cancer and contributes to transformed phenotypes.In this minireview, we discuss how hyper-O-GlcNAcylation may be linked to various hallmarks of cancer, including cancer cell proliferation, survival, invasion, and metastasis; energy metabolism; and epigenetics.We also discuss potential therapeutic modulation of O-GlcNAc levels in cancer treatment.* This is the fifth article in the Minireview Series on the Thirtieth Anniversary of Research on O-GlcNAcylation of Nuclear and Cytoplasmic Proteins: Nutrient Regulation of Cellular Metabolism and Physiology by O-GlcNAcylation.
Source: Journal of Biological Chemistry
Authors: Zhiyuan Ma, Keith Vosseller
Institution: Drexel University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2034827327