Work

Molecular layer detection on a diffractive optical balance

Year: 2012

Type: article

Abstract: Diffraction-based molecular detection is achieved by etching optical gratings into thermal oxide on silicon. The gratings perform as a stable common-path diffractive optical balance (DOB) designed to operate near a missing diffraction order. The biosensor is operated in an off-null condition with a phase bias to produce a high-contrast responsivity that is linear in accumulated molecules but with a low background. The DOB linear responsivity is a factor of 20 larger than the reflectometric responsivity of planar thermal oxide.

Source: Optics Letters

DOI: 10.1364/ol.37.004098

Authors: Xuefeng Wang, Ming Zhao, David D. Nolte

Institution: Purdue University West Lafayette

Language: English

Topic: Photorefractive and Nonlinear Optics

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: green

Funders: Purdue University, National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Multiplexed Assays on the BioCD for Acute Lymphocytic Leukemia, Immunomagnetic Diffractometry for Rapid Biomolecular Detection, G5818514098, G8052174210