Get started
Work

Role of Alginate O Acetylation in Resistance of MucoidPseudomonas aeruginosato Opsonic Phagocytosis

Year: 2001
Type: article
Abstract: Establishment and maintenance of chronic lung infections with mucoid Pseudomonas aeruginosa in patients with cystic fibrosis (CF) require that the bacteria avoid host defenses. Elaboration of the extracellular, O-acetylated mucoid exopolysaccharide, or alginate, is a major microbial factor in resistance to immune effectors. Here we show that O acetylation of alginate maximizes the resistance of mucoid P. aeruginosa to antibody-independent opsonic killing and is the molecular basis for the resistance of mucoid P. aeruginosa to normally nonopsonic but alginate-specific antibodies found in normal human sera and sera of infected CF patients. O acetylation of alginate appears to be critical for P. aeruginosa resistance to host immune effectors in CF patients.
DOI: 10.1128/iai.69.3.1895-1901.2001
Institutions: Brigham and Women's Hospital, Harvard University, Montana State University, Virginia Commonwealth University, Veterans Health Administration, Hunter Holmes McGuire VA Medical Center, Virginia Commonwealth University Medical Center
Language: English
Open Access status: green
OpenAlex ID: W2035006242
FWCI: 1.923
Cites: 50
Cited by: 263
Related to: 10