Work

Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior

Year: 2000

Type: article

Abstract: Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.97.13.7551

Authors: Anthony P. Auger, Marc J. Tetel, Margaret M. McCarthy

Institutions: University of Maryland, Baltimore, University of Massachusetts Amherst

Language: English

Topic: Sexual Differentiation and Disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Mental Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: AMINO ACID TRANSMITTERS AND BRAIN SEXUAL DIFFERENCES, G4069078134, ROLE OF SRC 1 IN SEXUAL DIFFERENTIATION OF RAT BRAIN, G9000200728, Neuroinflammation, Epigenetics and Male Vulnerability