Work

Mechanism-based inactivation of ribonuclease A

Year: 1995

Type: article

Abstract: , yields an iodophosphate. The resulting iodophosphate can then be coupled to a second alcohol, phenol, or enolate to give a phosphate triester, which after subsequent deprotection affords the desired phosphate diester. The novel phosphorylation chemistry presented should greatly facilitate the synthesis of other similar mechanism-based phosphodiesterase inhibitors.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo00126a051

Authors: Jeffrey K. Stowell, Theodore S. Widlanski, Tatiana G. Kutateladze, Ronald T. Raines

Institutions: Indiana University Bloomington, Indiana University, University of Wisconsin–Madison

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Protein Chemistry