Work

Dual Targeting of the Warburg Effect with a Glucose‐Conjugated Lactate Dehydrogenase Inhibitor

Year: 2013

Type: article

Abstract: Effective glucose diet: We report the development and activity of glucose-conjugated LDH-A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism.

Source: ChemBioChem

DOI: 10.1002/cbic.201300562

Authors: Emilia C. Calvaresi, Carlotta Granchi, Tiziano Tuccinardi, Valeria Di Bussolo, Robert W. Huigens, Hyang Yeon Lee, Rahul Palchaudhuri, Marco Macchia, Adriano Martinelli, Filippo Minutolo, Paul J. Hergenrother

Institutions: University of Illinois Urbana-Champaign, University of Pisa

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Public Health Service, National Cancer Institute, National Institute of General Medical Sciences

Awards: Design, Synthesis, and Evaluation of Lactate Dehydrogenase Inhibitors, Biological characterization of a novel class of lactate dehydrogenase A (LDH-A) i, G2490713250

OpenAlex ID: W2035196020

FWCI: 2.46

Cites: 55

Cited by: 56

Related to: 10