Work

Analysis of Stiffness in Extracellular Matrix Embedded with Bio-Conjugated Magnetic Beads in a Magnetic Field

Year: 2012

Type: article

Abstract: In this paper we present a new model for determining the local stiffness of an extracellular matrix (ECM) sample embedded with bio-conjugated magnetic beads under the influence of an external magnetic field.In this model, the viscoelastic deformation of such ECM samples is analyzed using the finite element method.We report results from numerical simulations using our model on two typical scenarios for studying the pre-tension in the ECM caused by beads under a magnetic field.The analytical results are in close agreement with that obtained from COMSOL.We also applied our model on an actual ECM sample embedded with bio-conjugated beads and compared our analytical results with that obtained from stretch tests done on that sample.These results are comparable to that from the stretching tests.

Source: International Journal of Bioscience Biochemistry and Bioinformatics

DOI: 10.7763/ijbbb.2012.v2.127

Authors: Yue Du, Sahan C. B. Herath, Qing-Guo Wang, Harry Asada, Peter C. Y. Chen

Institutions: National University of Singapore, Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National University of Singapore, China Scholarship Council

OpenAlex ID: W2035207355