Work

Are parkin patients particularly suited for deep‐brain stimulation?

Year: 2008

Type: article

Abstract: Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.

Source: Movement Disorders

DOI: 10.1002/mds.21903

Authors: Ebba Lohmann, Marie‐Laure Welter, Valérie Fraix, Paul Krack, Suzanne Lesage, Sophie Laine, Marie‐Laure Tanguy, Jean‐Luc Houeto, Valérie Mesnage, Pierre Pollak, Alexandra Durr, Yves Agid, Alexis Brice, French Parkinson's Disease Genetics study group

Institutions: Inserm, Pitié-Salpêtrière Hospital, Université Pierre-et-Marie-Curie, Assistance Publique – Hôpitaux de Paris, Centre Hospitalier Universitaire de Grenoble, Centre Hospitalier Universitaire de Poitiers, Université Joseph Fourier

Language: English

Topic: Neurological disorders and treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: European Commission, Institut National de la Santé et de la Recherche Médicale, Assistance Publique - Hôpitaux de Paris, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: G3943096544, Parkin mutations and their functional consequences, G577149390, G9000139048

OpenAlex ID: W2035399724

FWCI: 1.488

Cites: 15

Cited by: 38

Related to: 10