P1‐245: Mapping local structural hippocampal changes in Alzheimer's disease and normal aging on MR imaging at 3T
Year: 2008
Type: article
Study design: Observational Study
Abstract: Histological studies suggest that hippocampal subfields are differently affected by aging and Alzheimer's disease. We aimed to study local hippocampal changes in aging and moderate to severe Alzheimer's patients based on high resolution magnetic resonance images at 3 Tesla. 3D high resolution T1-weighted magnetic resonance (MR) were acquired on a 3.0 T scanner from 14 AD (age 75±5 years, 3 males, Mini Mental State Examination 13±4) and 14 controls (age 71±5 years 9 males, Mini-Mental State Examination 29±1). The hippocampal formation was isolated by manual tracing. Radial Atrophy Mapping was used to assess group differences and correlations by averaging hippocampal shapes across subjects using 3-dimensional parametric surface mesh models. Percentage difference, Pearson's r, and significance 3-dimensional maps were produced. Hippocampal volumes were inversely correlated with age in older healthy controls (r= .53 and .56 to the right and left, p< 0,05, corresponding to 17% lower volume for every 10 years of older age from age 65). Aging-associated atrophy mapped to dorsal and lateral areas of the tail and body corresponding to the CA1 subfield and to ventral areas of the head corresponding to the subiculum. Significantly increased volume with older age mainly mapped to restricted dorsal areas of the head bilaterally corresponding to the CA1 subfield. Volumes were 37% and 30% smaller in AD patients to the right and left (p<.0005). AD-associated atrophy mapped to areas of the body and tail corresponding to those also associated with age, and dorsal areas of the head corresponding to the CA1 subfield unaffected by age. Regions corresponding to the CA2–3 fields were relatively spared in both aging and AD. Hippocampal atrophy in AD maps to areas in the body and tail partly overlapping to those affected by normal aging. Specific areas in the anterior and dorsal CA1 subfield involved in AD were not in normal aging. Such differences might relate to specific systems being involved in AD and ageing.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2035443339