Work

Sickle cell disease: old discoveries, new concepts, and future promise

Year: 2007

Type: review

Abstract: The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci30920

Authors: Paul S. Frenette, George F. Atweh

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute