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Autoimmune Hemolytic Anemia in Myelodysplastic Syndrome

Year: 2006

Type: article

Abstract: Autoimmune paraneoplastic syndromes are encountered in patients with myelodysplastic syndromes.A review of case reports suggested 10% of myelodysplastic syndrome patients may experience various autoimmune syndromes, associated with immunological-mediated hematologic abnormalities, such as Coombs' negative hemolytic anemia.In patients with myelodysplastic syndrome, Coombs' negative hemolytic anemia may be underdiagnosed due to its association with reticulocytopenia.Therefore, the findings from a peripheral blood smear and measurement of haptoglobin level are important.Autoimmune manifestations respond to immunosuppressive agents, including steroids.Herein, a case with Coombs' negative hemolytic anemia, diagnosed with myelodysplastic syndrome from a bone marrow biopsy, is reported, with a review of the previously reported literature.(

Source: The Korean Journal of Hematology

DOI: 10.5045/kjh.2006.41.4.317