Work

FGFR Fusions in the Driver's Seat

Year: 2013

Type: article

Abstract: Summary: Through a clinical deep sequencing protocol, Wu and colleagues have identified multiple FGFR fusion proteins in diverse cancers. Pharmacologic inhibition of FGFR suppressed the growth of FGFR fusion–positive tumor models, suggesting that these FGFR fusions are oncogenic drivers and highlighting the use of streamlined clinical sequencing efforts to identify novel, actionable driver oncoproteins in human tumors. Cancer Discov; 3(6); 607–9. ©2013 AACR. See related article by Wu et al., p. 636

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-13-0185

Authors: Amit J. Sabnis, Trever G. Bivona

Institutions: University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center

Language: English

Topic: Fibroblast Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute