Work

Geometry of the nucleus: a perspective on gene expression regulation

Year: 2014

Type: review

Abstract: Gene expression control results from the combined interactions of the nearly hundred proteins forming the pre-initiation complex, thousands of transcription regulators, and genomic DNA. In the recent years, new technologies have revealed several key aspects of nuclear spatial organization that showed a fine interplay between the function of nuclear proteins, their 3D organization, and their dynamics. Here we review several concepts that link biochemical reactivity in the nucleus to its 3D spatial organization. We present the analogies between the emerging understanding of nuclear organization in the field of cell biology, and the more established disciplines of heterogeneous catalysis and the physics of random walks. We provide several recent examples showing how nuclear geometry affects protein reactivity in the nucleus.

Source: Current Opinion in Chemical Biology

DOI: 10.1016/j.cbpa.2014.05.009

Authors: Maxime Woringer, Xavier Darzacq, Ignacio Izeddin

Institutions: Centre National de la Recherche Scientifique, Inserm, École Normale Supérieure - PSL, Institut de Biologie de l'École Normale Supérieure

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,510

Funder: Agence Nationale de la Recherche