Work

Enhanced liposome-mediated activity of piperacillin against staphylococci

Year: 1985

Type: article

Abstract: This study showed that encapsulation of the beta-lactam antibiotic piperacillin (PIP) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) protected the drug from hydrolysis by staphylococcal beta-lactamase. This was demonstrated by growth inhibition of Staphylococcus aureus in the presence of the liposomal preparation containing PIP at a 50% MIC. Growth inhibition was also seen when exogenous beta-lactamase was added. Furthermore, adsorption of PIP onto the surface of liposomes containing buffer conferred a significant degree of protection against enzymatic hydrolysis of the drug, thus enhancing its antistaphylococcal activity.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.27.1.137

Authors: M C Nacucchio, M J Bellora, D O Sordelli, M D'Aquino

Institutions: Universidad de Buenos Aires, Georgetown University Medical Center

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2035833314

FWCI: 1.352

Cites: 16

Cited by: 60

Related to: 10