Work

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models

Year: 2014

Type: article

Abstract: The study of pancreatic cancer has prompted the development of numerous mouse models that aim to recapitulate the phenotypic and mechanistic features of this deadly malignancy. This review accomplishes two tasks. First, it provides an overview of the models that have been used as representations of both the neoplastic and carcinoma phenotypes. Second, it presents new modeling schemes that ultimately will serve to more faithfully capture the temporal and spatial progression of the human disease, providing platforms for improved understanding of the role of non-epithelial compartments in disease etiology as well as evaluating therapeutic approaches.

Source: Frontiers in Physiology

DOI: 10.3389/fphys.2014.00464

Authors: Brian T. DeCant, Daniel R. Principe, Carmen Guerra, Marina Pasca di Magliano, Paul J. Grippo

Institutions: University of Illinois Chicago, Spanish National Cancer Research Centre, University of Michigan

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801