Work

Contribution of mitochondria to cardiac muscle water/macromolecule proton magnetization transfer

Year: 2003

Type: article

Abstract: The contribution of mitochondria to water-macromolecule proton magnetization transfer (MT) was evaluated in porcine heart tissue. An examination of isolated mitochondria in suspension, at the same concentration as found in heart tissue, revealed MT effects very similar in magnitude and bandwidth to those in intact heart tissue. Disruption of the gross structure of the mitochondria by freeze-thawing or with detergent resulted in only approximately 25% decreases in MT, which suggests that the structure of the mitochondria is not critical for these effects. The current data indicate that mitochondria macromolecules contribute significantly to MT in the intact heart.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/mrm.10625

Authors: Kathleen Ward, Adam E. Schussheim, Robert S. Balaban

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,680