Year: 1995
Type: review
Abstract: Functional and structural inter-relationships of RNA and proteins in the execution and control of biological processes such as RNA processing, RNA splicing, and translation are increasingly apparent. In this minireview, I present an RNA chaperone hypothesis, which fosters the view that constraints imposed by fundamental problems in the folding of RNA have profoundly influenced the nature of RNA/protein interactions in biology. The origin of this view is outlined as follows. RNA has two fundamental folding problems: a tendency to fold into and become kinetically trapped in alternative conformations and a difficulty in specifying a single tertiary structure that is thermodynamically strongly favored over competing structures.
Source: Journal of Biological Chemistry
Author: Daniel Herschlag
Institution: Stanford University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
Awards: G3262139953, G9000082247
OpenAlex ID: W2036116609