Work

Late effects of radiation therapy in the head and neck region

Year: 1995

Type: review

Abstract: The head and neck region is composed of numerous structures, each with an inherent response to radiation that is largely governed by the presence or absence of mucosa, salivary glands, or specialized organs within that site. Irradiated mucocutaneous tissues demonstrate increased vascular permeability that leads to fibrin deposition, subsequent collagen formation, and eventual fibrosis. Irradiated salivary tissue degenerates after relatively small doses, leading to markedly diminished salivary output. This, in turn, effects the teeth by promoting dental decay which, in turn, effects the integrity of the mandible. Details of these changes are presented, including their pathophysiology, clinical syndromes, and potential treatment.

Source: International Journal of Radiation Oncology*Biology*Physics

DOI: 10.1016/0360-3016(94)00421-g

Authors: Jay S. Cooper, Karen Fu, James Marks, Sol Silverman

Institutions: NYU Langone Health, University of California, San Francisco

Language: English

Topic: Oral health in cancer treatment

Subfield: General Dentistry

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,130