Work

Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow

Year: 2014

Type: review

Abstract: Nitric oxide (NO) maintains cardiovascular health by activating soluble guanylate cyclase (sGC) to increase cellular cGMP levels. Cardiovascular disease is characterized by decreased NO-sGC-cGMP signaling. Pharmacological activators and stimulators of sGC are being actively pursued as therapies for acute heart failure and pulmonary hypertension. Here we review molecular mechanisms that modulate sGC activity while emphasizing a novel biochemical pathway in which binding of the matricellular protein thrombospondin-1 (TSP1) to the cell surface receptor CD47 causes inhibition of sGC. We discuss the therapeutic implications of this pathway for blood flow, tissue perfusion, and cell survival under physiologic and disease conditions.

Source: Frontiers in Physiology

DOI: 10.3389/fphys.2014.00134

Authors: Natasha M. Rogers, Franziska Seeger, Elsa D. Garcin, David D. Roberts, Jeffrey S. Isenberg

Institutions: University of Pittsburgh, University of Maryland, Baltimore County, National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801