Work

Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome

Year: 2007

Type: article

Abstract: Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility to cell death. We have studied apoptosis and mitochondrial (mt) membrane potential (DeltaPsi(m)) in peripheral blood mononuclear cells (PBMC) from DS children and age-matched healthy donors after in vitro treatment with apoptogenic molecules, along with mtDNA content. We found that PBMC from DS and healthy controls had a similar tendency to undergo apoptosis and a similar amount of mtDNA. However, in cells from DS subjects, mitochondria showed a higher loss of DeltaPsi(m), underlying the presence of an increasing susceptibility of these organelles to damaging agents.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2006.12.058

Authors: Erika Roat, Nicole Prada, Roberta Ferraresi, Chiara Giovenzana, Milena Nasi, Leonarda Troiano, Marcello Pinti, Elisa Nemes, Enrico Lugli, Ornella Biagioni, Mauro Mariotti, Luigi Ciacci, Ugo Consolo, Fiorella Balli, Andrea Cossarizza

Institutions: University of Modena and Reggio Emilia, University of Palermo

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2036468843

FWCI: 1.588

Cites: 29

Cited by: 51

Related to: 10