Work

High resolution profiling of DNA copy number and gene expression changes in AIDS-related lymphoma

Year: 2009

Type: article

Abstract: The incidence of B cell non-Hodgkin lymphoma (NHL) is increased substantially in the HIV-1-infected immunosuppressed population.Clinically, AIDS-related lymphoma (ARL) is more aggressive and has a worse prognosis than in non-immunocompromised patients, though there has been significant improvement in the post-HAART era.While HIV-induced immunosuppression, chronic antigenic stimulation, and cytokine overproduction may contribute to differences in disease progression and outcome, distinct genetic changes in ARL may also mediate these effects.Chromosomal DNA copy number alterations are known to play a major role in lymphomagenesis and have been studied in non immunocompromised patients for some NHLs.

Source: Infectious Agents and Cancer

DOI: 10.1186/1750-9378-4-s2-o8

Authors: KE Deffenbacher, Z Liu, J Iqbal, H Geng, K Fu, WC Chan

Institution: University of Nebraska Medical Center

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190