Tumor Necrosis Factor Receptor/Tumor Necrosis Factor Family Members in Antiviral CD8 T-Cell Immunity
Year: 2010
Type: article
Abstract: CD8 memory T cells can play a critical role in protection against repeated exposure to infectious agents such as viruses, yet can also contribute to the immunopathology associated with these pathogens. Understanding the mechanisms that control effective memory responses has important ramifications for vaccine design and in the management of adverse immune reactions. Recent studies have implicated several members of the tumor necrosis factor receptor (TNFR) family as key stimulatory and inhibitory molecules involved in the regulation of CD8 T cells. In this review, we discuss their control of the generation, persistence, and reactivation of CD8 T cells during virus infection.
Authors: Shahram Salek-Ardakani, Michael Croft
Institution: La Jolla Institute for Immunology
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1453815790, G1657500643, G2050848827, TNFR Members in T Cell Immunity to Vaccinia, G218382676, Induction and maintenance of regulatory T cells, G3353305694, G356969442, TNFR Members in T Cell Immunity to Vaccinia, G4126962603, G4548873109, G5156247103, G7306363265, G7445370438, G9000034789, G9000097582, Airway Inflammation and Airway Remodeling in Severe Asthma
OpenAlex ID: W2036627544