Work

The role of sirtuin proteins in obesity

Year: 2008

Type: article

Abstract: Although the progressive metabolic changes associated with obesity are complex, it is well-recognized that obesity is a risk factor for the development of insulin resistance and type 2 diabetes. Because both obesity and type 2 diabetes are associated with insulin resistance, there is significant interest in defining the mechanistic basis for insulin resistance. Recent studies involving SIRT1, the most intensely studied sirtuin family member, have shown that it regulates many metabolic adaptations linked with obesity. SIRT1 has been shown to regulate the expression of adipokines, repress the activity of factors required for maturation of fat cells, regulate insulin secretion, modulate plasma glucose levels and insulin sensitivity and alter mitochondrial capacity. Moreover, some investigators have suggested that altering SIRT1 activity may be a promising new therapy for type 2 diabetes. In this review we focus on the role of sirtuins in obesity with particular emphasis on the contribution of SIRT1.

Source: Pathophysiology

DOI: 10.1016/j.pathophys.2008.04.002

Authors: Cheynita F. Metoyer, Kevin Pruitt

Institutions: Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center Shreveport

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,689