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Ion channel modulation as the basis for general anesthesia

Year: 1998
Type: article
Abstract: (1) Modulation of the function of the GABA(A) and neuronal nicotinic acetylcholine receptor channels caused by general anesthetics and modulation of the GABA(A) receptor-channel by halothane, enflurane, isoflurane, and n-octanol was channel state-dependent. (3) Halothane modulation of the GABA(A) receptor was independent of subunits, but n-octanol modulation was subunit-dependent. (4) Ethanol at 30-100 microM was very potent in accelerating the desensitization of currents induced by acetylcholine. (5) The ethanol modulation was subunit- and state-dependent, occurring in the alpha3beta4 combination but only weakly in the alpha3beta2 combination. (6) In contrast, halothane at 430 microM (approximately 1 MAC) potently suppressed ACh-induced currents in the alpha3beta2 subunit combination.
DOI: 10.1016/s0378-4274(98)00184-2
Authors: Toshio Narahashi, Gary L Aistrup, Jon M Lindstrom, William Marszalec, Keiichi Nagata, Fan Wang, Jay Z Yeh
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,270
Awards: G12222047, G1328730415, CELLULAR NEUROPHYSIOLOGICAL STUDY OF DRUG ACTION, ETHANOL ON GABA A RECEPTOR INTRACELLULAR REGULATION, Studies using purified acetylcholine receptors, CELLULAR MECHANISMS OF ACTION OF ALCOHOL, G4700852728, G8091883331, G9000040999
OpenAlex ID: W2037032971
FWCI: 0.783
Cites: 22
Cited by: 28
Related to: 10