Year: 2014
Type: review
Abstract: Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Recent studies have established the importance of several evolutionarily conserved mechanisms for heart regeneration in lower vertebrates and neonatal mammals including induction of cardiomyocyte proliferation, epicardial cell activation, angiogenesis, extracellular matrix deposition and immune cell infiltration. In this review, we provide an up-to-date account of the molecular and cellular basis for cardiac regeneration in lower vertebrates and neonatal mammals. The historical context for these recent findings and their ramifications for the future development of cardiac regenerative therapies are also discussed.
Source: Stem Cell Research
Authors: Enzo R. Porrello, Eric N. Olson
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,360
Funders: Welch Foundation, American Heart Association, Cancer Prevention and Research Institute of Texas, National Heart Foundation of Australia, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: Deciphering a Regulatory Circuit for Myocardial Metabolism and Energy Homeostasis, Heart Repair through Reprogramming of Cardiac Cell Fate, MicroRNA Control of Cardiac Gene Expression, Function and Disease, Microenvironmental control of progenitors in organ dysfunction and repair, G662211534, Metabolic Control by Myogenic MicroRNAs, Mediator and Myokines, Understanding how the newborn heart regenerates following injury., G8791572683
OpenAlex ID: W2037250671