Work

Sequence and expression of the rat prodynorphin gene.

Year: 1985

Type: article

Abstract: We report here the isolation of a lambda genomic clone that contains the nucleotide sequence coding for the main exon of the rat prodynorphin (proenkephalin B) gene. This exon codes for the majority of the translated region of prodynorphin mRNA including the opioid peptides alpha-neo-endorphin, dynorphin A, and dynorphin B. The entire 3' untranslated region is also contained on the lambda clone. Nucleotide sequence comparison with the main exon of the human prodynorphin gene reveals both structural and sequence homology. RNA blot analysis reveals that prodynorphin transcripts can be seen in numerous regions of the rat brain and in the adrenal gland, spinal cord, testis, and anterior pituitary.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.82.12.4291

Authors: O Civelli, J Douglass, A Goldstein, E Herbert

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: REGULATION OF EXPRESSION OF OPIOID PEPTIDES &RECEPTORS, REGULATION OF PROCESSING OF OPIOID PEPTIDE PRECURSORS, G3422730711

OpenAlex ID: W2037373352

FWCI: 5.953

Cites: 31

Cited by: 384

Related to: 10