Work

Neuropathological features of Alzheimer's disease in non-demented parkinsonian patients.

Year: 1991

Type: article

Abstract: Two patients with levodopa-responsive Parkinson's syndrome had numerous cortical and striatal senile plaques and some neurofibrillary tangles at necropsy. In addition neurons in the pars compacta of the substantia nigra were severely depleted but there were no Lewy bodies or other neuropathological changes to account for parkinsonism. Neither patient was demented. These pathological findings have not previously been described as a cause of Parkinson's syndrome without associated dementia of Alzheimer's disease type.

Source: Journal of Neurology Neurosurgery & Psychiatry

DOI: 10.1136/jnnp.54.11.972

Authors: S E Daniel, A J Lees

Institution: UCL Queen Square Institute of Neurology

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Parkinson's UK, Medical Research Council