Work

Spatz-Lindenberg Disease

Year: 1999

Type: article

Abstract: BACKGROUND: Isolated cerebral thromboangiitis obliterans (Spatz-Lindenberg disease) is not well recognized as a cause of vascular dementia. CASE DESCRIPTION: A 58-year-old woman presented with dementia and pyramidal signs. Neuroimaging showed multiple areas of white matter change. Brain biopsy showed intimal thickening of the walls of leptomeningeal and intraparenchymal arteries, almost to complete occlusion, with an intact internal elastic lamina and media and without inflammation or infiltration. The cortex showed only moderate gliosis. CONCLUSIONS: Spatz-Lindenberg disease should be considered in the differential diagnosis of vascular dementia. Additional studies of its pathogenesis are required to determine appropriate treatment.

Source: Stroke

DOI: 10.1161/01.str.30.3.687

Authors: A. J. Larner, Desmond Kidd, Paul Elkington, Peter Rudge, Francesco Scaravilli

Institution: National Hospital for Neurology and Neurosurgery

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2037596258

FWCI: 1.277

Cites: 10

Cited by: 13

Related to: 10